Sustained amphiregulin expression in intermediate alveolar stem cells drives progressive fibrosis
Rui Zhao, Zheng Wang, Guowu Wang, Jing Geng, Huijuan Wu, Ximing Liu, Ennan Bin, Jianhua Sui, Huaping Dai, Nan Tang
Tang and colleagues elucidated the profibrotic role of sustained amphiregulin (AREG) derived from intermediate lung stem cells in driving pulmonary fibrosis and established AREG as a potential disease-severity indicator for idiopathic pulmonary fibrosis. Pharmacological inhibition of AREG may serve as a new therapeutic strategy for treating fibrotic diseases.
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration
Zheng Wang, Dongdong Wei, Ennan Bin, Jiao Li, Kewu Jiang, Tingting Lv, Xiaoxu Mao, Fengchao Wang, Huaping Dai, Nan Tang
Tang and colleagues elucidate the mechanisms governing alveolar regeneration and the impact of aging on post-injury alveolar regeneration, highlighting that cellular energy metabolism is orchestrated with stem cell differentiation during alveolar regeneration. Their findings suggest therapeutic potential for aging-related lung diseases through targeted modulation of stem cell energy metabolism.
Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells
Huijuan Wu, Yuanyuan Yu, Huanwei Huang, Yucheng Hu, Siling Fu, Zheng Wang, Mengting Shi, Xi Zhao, Jie Yuan, Jiao Li, Xueyi Yang, Ennan Bin, Dong Wei, Hongbin Zhang, Jin Zhang, Chun Yang, Tao Cai, Huaping Dai, Jingyu Chen, Nan Tang